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To establish the importance of the NEP-derived metabolite GLP-1(2836) to the overall cardiovascular biology of GLP-1, we used sacubitril, a pharmacological inhibitor of NEP, and assessed in vitro cAMP accumulation in caSMCs, as well as functional LVDP recovery in an ex vivo Langendorff model of IRI

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By effectively addressing obesity, Semaglutide not only improves physical health outcomes but also contributes to enhancing mental well-being, potentially reducing the incidence of depression and suicidal thoughts

previous cardiovascular, cerebrovascular or peripheral vascular disease), heart failure or CKD (eGFR 30 kg/m 2 in all groups

10.1007/s00394-004-0472-4 95 TayebM